LAX1 Antibody, HRP conjugated

Datasheet

Code	CSB-PA811614LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LAX1 Polyclonal antibody

Uniprot No.

Q8IWV1

Target Names

LAX1

Alternative Names

LAX1 antibody; LAX antibody; Lymphocyte transmembrane adapter 1 antibody; Linker for activation of X cells antibody; Membrane-associated adapter protein LAX antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Lymphocyte transmembrane adapter 1 protein (107-298AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.

Gene References into Functions

TRIM required LAX for binding to Rab8 in a complex, a novel CTLA-4/TRIM/LAX/Rab8 effector complex in the transport of CTLA-4 to the surfaces of T cells PMID: 24515439
We identified the transmembrane domain of LAX as a first motif targeting transmembrane protein constructs to detergent-resistant heavy rafts, a novel type of membrane microdomains containing a number of physiologically important proteins. PMID: 22662118
functions to negatively regulate signaling in lymphocytes PMID: 12359715
inhibition of signaling events involved in T cell activation by LAX occurs through mechanisms both dependent on and independent of its tyrosine phosphorylation. PMID: 18981125
Overexpression of LAX in Jurkat cells specifically inhibits T cell receptor-mediated p38 MAPK activation and NFAT/AP-1 transcriptional activation. PMID: 12359715

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Subcellular Location

Cell membrane; Single-pass type III membrane protein.

Tissue Specificity

Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.

Database Links

HGNC: 26005

KEGG: hsa:54900

STRING: 9606.ENSP00000406970

UniGene: Hs.272794

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Phage Display Service

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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